Leveraging currently available high-resolution chromatin organizational data (Micro-C) on H1-ESC and HFF, CAESAR imputes high-resolution contact maps for 90 human tissues/cell-types from low-resolution Hi-C and epigenomic features. CAESAR imputes all chromatin contacts with genomic distances less than 200 kb, which cover most fine-scale structures (e.g., loops and stripes) discovered by Micro-C. CAESAR web server allows users to explore these high-resolution chromatin contact maps at 1 kb resolution. For specific fine-scale chromatin structures (e.g., loops or stripes), CAESAR uses integrated gradient to identify the responsible epigenomic features during the imputation. In the web server, the user can choose arbitrary regions for attribution calculation and the results will be visualized below the contact map.

Leveraging currently available high-resolution chromatin organizational data (Micro-C) on H1-ESC and HFF, CAESAR imputes high-resolution contact maps for 90 human tissues/cell types from low-resolution Hi-C and epigenomic features. CAESAR imputes all chromatin contacts with genomic distances less than 200 kb, which cover most fine-scale structures (e.g., loops and stripes) discovered by Micro-C. CAESAR web server allows users to explore these high-resolution chromatin contact maps at 1 kb resolution. For specific fine-scale chromatin structures (e.g., loops or stripes), CAESAR uses integrated gradient to identify the responsible epigenomic features during the imputation. In the web server, the user can choose arbitrary regions for attribution calculation and the results will be visualized below the contact map.

Connecting high-resolution 3D chromatin organization with epigenomics
Fan Feng, Yuan Yao, Xue Qing David Wang, Xiaotian Zhang, Jie Liu. Nat Commun 13, 2054 (2022); doi: https://doi.org/10.1038/s41467-022-29695-6